Laminin isoforms and lung development: All isoforms are not equal
نویسندگان
چکیده
منابع مشابه
Self-assembly of laminin isoforms.
The alpha, beta, and gamma subunits of basement membrane laminins can combine into different heterotrimeric molecules with either three full short arms (e.g. laminins-1-4), or molecules containing one (laminins-6-9) or more (laminin-5) short arm truncations. Laminin-1 (alpha1beta1gamma1), self-assembles through a calcium-dependent thermal gelation requiring binding interactions between N-termin...
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To the Editor: Gibbons et al1 detail the “noble” and Herculean task of developing American College of Cardiology/American Heart Association cardiovascular guidelines. Recommendations are based on either experimental results or opinion, with the latter being considered of uniformly lower evidentiary importance. The contribution of opinion to the guidelines is substantial in that opinion supports...
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Cells undergo many structural-mechanical changes as an inextricable component of cellular motility, cytokinesis, and changes in cell shape. The mere act of receptor-mediated adhesion to extracellular matrix involves massive changes in cytoskeletal organization, spreading, and flattening of cells against the matrix, and the generation of traction forces through the contractile activity of cells....
متن کاملLaminin Isoforms and Laminin-Producing Cells in Rat Anterior Pituitary
Laminin is a key component of the basement membrane and is involved in the structural scaffold and in cell proliferation and differentiation. Research has identified 19 laminin isoforms, which are assemblies of α, β, and γ chains (eg, the α1, β1, and γ1 chains form the laminin 111 isoform). Although laminin is known to be present in the anterior pituitary, the specific laminin isoforms have not...
متن کاملLaminin isoforms in human extraocular muscles.
PURPOSE To determine the laminin isoform composition of the basement membranes (BMs) in the human extraocular muscles (EOMs) and relate it to the fact that EOMs are spared in laminin alpha2-chain-deficient congenital muscular dystrophy. METHODS Samples from adult human EOMs and limb muscle were processed for immunocytochemistry, with monoclonal antibodies against laminin chains (Ln) alpha1 to...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2006
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.03.032